NutriStack
Alpha-GPC and Donepezil, a caution.
Both donepezil and Alpha-GPC increase cholinergic activity. Donepezil inhibits acetylcholinesterase; Alpha-GPC provides choline for acetylcholine synthesis. Combined use may cause cholinergic excess (nausea, diarrhea, bradycardia).
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both donepezil and Alpha-GPC increase cholinergic activity. Donepezil inhibits acetylcholinesterase; Alpha-GPC provides choline for acetylcholine synthesis. Combined use may cause cholinergic excess (nausea, diarrhea, bradycardia).
Mechanism. Donepezil inhibits AChE, increasing synaptic ACh. Alpha-GPC provides additional choline substrate for ACh synthesis. Dual cholinergic enhancement can cause parasympathomimetic excess.
Recommendation. If combining, start Alpha-GPC at low doses (300mg) and monitor for cholinergic side effects (nausea, diarrhea, muscle cramps, bradycardia).
Sources (4)
- De Jesus Moreno Moreno M. Cognitive improvement in mild to moderate Alzheimer's dementia after treatment with the acetylcholine precursor choline alfoscerate. Clin Ther. 2003;25(1):178-193. PMID 12637119
- Kerksick CM. Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men. Nutrients. 2024. PMID 39683633
- Sagaro GG, Traini E, Amenta F. Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis. J Alzheimers Dis. 2023. PMID 36683513
- Yamashita S, Kawada N, Wang W et al.. Effects of egg yolk choline intake on cognitive functions and plasma choline levels in healthy middle-aged and older Japanese: a randomized double-blinded placebo-controlled parallel-group study. Lipids Health Dis. 2023. PMID 37340479
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alpha-GPC and Donepezil are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.