NutriStack
Donepezil and Ginkgo Biloba, a caution.
Both donepezil and ginkgo biloba have cholinergic and cognitive effects. Some studies have explored the combination, but additive cholinergic side effects and ginkgo's antiplatelet activity warrant caution.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Donepezil and Ginkgo Biloba
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 3 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Both donepezil and ginkgo biloba have cholinergic and cognitive effects. Some studies have explored the combination, but additive cholinergic side effects and ginkgo's antiplatelet activity warrant caution.
Mechanism. Ginkgo biloba inhibits platelet-activating factor (PAF) and may have mild AChE inhibitory effects. Combined with donepezil's potent AChE inhibition, cholinergic effects may be additive.
Recommendation. May be used under medical supervision for cognitive support. Monitor for GI side effects and bleeding signs.
Sources (3)
- Yancheva S et al. Ginkgo biloba extract EGb 761, donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features. Aging Ment Health. 2009;13(2):183-190. PMID 19347685
- Mousavi SN, Hosseinikia M, Yousefi Rad E, Saboori S. Beneficial effects of Ginkgo biloba leaf extract on inflammatory markers: A systematic review and meta-analysis of the clinical trials. Phytotherapy Research. 2022. PMID 35781715
- Tabrizi R, Nowrouzi-Sohrabi P, Hessami K et al.. Effects of Ginkgo biloba intake on cardiometabolic parameters in patients with type 2 diabetes mellitus: A systematic review and meta-analysis of clinical trials. Phytotherapy Research. 2020. PMID 33090588
Stack Score
How this pair moves the number.
Effect on the composite score
If both Donepezil and Ginkgo Biloba are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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