NutriStack
Alpha-Lipoic Acid and Vitamin B5, a conflict.
Pantothenate (B5) also uses the SMVT transporter and may compete with alpha-lipoic acid for absorption.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alpha-Lipoic Acid and Vitamin B5
- Pair type
- Conflict
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −10 to your Stack Score (per scored conflict row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Conflict · Emerging evidence
Conflict
What is happening. Pantothenate (B5) also uses the SMVT transporter and may compete with alpha-lipoic acid for absorption.
Mechanism. SMVT (SLC5A6) transports pantothenate, biotin, and lipoate. High-dose ALA can reduce pantothenate absorption through competitive inhibition.
Recommendation. Separate by 2 hours if taking high doses of either. At typical supplement doses, competition is minimal.
Minimum separation. 120
Sources (1)
- Prasad PD et al. Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter. J Biol Chem. 1998
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alpha-Lipoic Acid and Vitamin B5 are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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