NutriStack
Amoxicillin-Clavulanate and Lactobacillus Rhamnosus, a synergy.
Lactobacillus rhamnosus GG reduces the elevated antibiotic-associated diarrhea risk associated with amoxicillin-clavulanate, including in pediatric patients. Separation from antibiotic dosing preserves bacterial viability.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
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At a glance
- Substances
- Amoxicillin-Clavulanate and Lactobacillus Rhamnosus
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Lactobacillus rhamnosus GG reduces the elevated antibiotic-associated diarrhea risk associated with amoxicillin-clavulanate, including in pediatric patients. Separation from antibiotic dosing preserves bacterial viability.
Mechanism. L. rhamnosus restores colonization resistance and competes with opportunistic pathogens for intestinal binding sites; it also supports gut barrier integrity through short-chain fatty acid production.
Recommendation. Take Lactobacillus rhamnosus throughout your amoxicillin-clavulanate course, separated by at least 2 hours from each antibiotic dose. Continue for at least 1 week after the antibiotic ends.
Minimum separation. 120
Sources (2)
- Barnes D, Yeh AM. Bugs and Guts: Practical Applications of Probiotics for Gastrointestinal Disorders in Children. Nutr Clin Pract. 2015;30(6):747-59. PMID 26538058
- Doar NW, Samuthiram SD. Qualitative Analysis of the Efficacy of Probiotic Strains in the Prevention of Antibiotic-Associated Diarrhea. Cureus. 2023;15(6):e40261. PMID 37440799
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amoxicillin-Clavulanate and Lactobacillus Rhamnosus are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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