NutriStack
Amoxicillin-Clavulanate and Saccharomyces Boulardii, a synergy.
Saccharomyces boulardii reduces the elevated antibiotic-associated diarrhea risk of amoxicillin-clavulanate. Because it is a yeast, it is unaffected by the antibiotic and timing is less critical than with bacterial probiotics.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
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At a glance
- Substances
- Amoxicillin-Clavulanate and Saccharomyces Boulardii
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Saccharomyces boulardii reduces the elevated antibiotic-associated diarrhea risk of amoxicillin-clavulanate. Because it is a yeast, it is unaffected by the antibiotic and timing is less critical than with bacterial probiotics.
Mechanism. S. boulardii produces proteases that degrade C. difficile toxins, stimulates secretory IgA, and competes with pathogens for adhesion sites. As a yeast, it is intrinsically resistant to antibacterial drugs.
Recommendation. Take Saccharomyces boulardii throughout your amoxicillin-clavulanate course. Timing flexibility is greater than with bacterial probiotics. Continue for at least 1 week after the antibiotic ends.
Sources (2)
- McFarland LV. Probiotics for the Primary and Secondary Prevention of C. difficile Infections: A Meta-analysis and Systematic Review. Antibiotics (Basel). 2015;4(2):160-78. PMID 27025619
- Boddy AV, Elmer GW, McFarland LV, Levy RH. Influence of antibiotics on the recovery and kinetics of Saccharomyces boulardii in rats. Pharm Res. 1991;8(6):796-800. PMID 2062812
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amoxicillin-Clavulanate and Saccharomyces Boulardii are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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