NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Amoxicillin and Saccharomyces Boulardii: what the published research says

PubMed indexes 8 records that name Amoxicillin and Saccharomyces Boulardii together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Amoxicillin and Saccharomyces Boulardii. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Amoxicillin and Saccharomyces Boulardii.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Vonoprazan-Amoxicillin Dual Therapy with or Without Saccharomyces boulardii Supplementation as a Rescue Regimen for Helicobacter pylori Infection.

Infection and drug resistance · 2026 · PMID 41971394

Case ReportsClinical Trial

“Supplementing vonoprazan-amoxicillin dual therapy with S. boulardii significantly increases H. pylori eradication rates and reduces adverse events, offering an effective and simple rescue treatment unaffected by previous treatment failures.”

Qu et al. · Authors' conclusion

Names both Amoxicillin and Saccharomyces Boulardii in its title.

Effectiveness and safety of vonoprazan and amoxicillin dual regimen with Saccharomyces boulardii supplements on eradication of Helicobacter pylori.

BMC gastroenterology · 2024 · PMID 39592940

Randomized Controlled Trial

“Addition of S. boulardii to VA-dual for 10 days is as effective as the 14-days bismuth-based quadruple regimen while ensuring fewer adverse events and lesser cost. This regimen is particularly suitable for low-BSA patients or non-smokers.”

Yu et al. · Authors' conclusion

Names both Amoxicillin and Saccharomyces Boulardii in its title.

Prospective randomized controlled study on the effects of Saccharomyces boulardii CNCM I-745 and amoxicillin-clavulanate or the combination on the gut microbiota of healthy volunteers.

Gut microbes · 2017 · PMID 27973989

Randomized Controlled TrialResearch Support, N.I.H., Extramural

“S. boulardii treatment can mitigate some antibiotic-induced microbiota changes (dysbiosis) and can also reduce antibiotic-associated diarrhea.”

Kabbani et al. · From the abstract

Names both Amoxicillin and Saccharomyces Boulardii in its title.

Vonoprazan-amoxicillin dual regimen with Saccharomyces boulardii as a rescue therapy for Helicobacter pylori: Current perspectives and implications.

World journal of gastroenterology · 2024 · PMID 38596495

EditorialHuman subjects

“boulardii comes in various formulations and dosages, warranting further exploration into the optimal dosage for supplementation in rescue therapy. Additionally, larger, randomized, double-blinded controlled trials are warranted to confirm these promising results.”

Dirjayanto et al. · From the abstract

Names both Amoxicillin and Saccharomyces Boulardii in its title.

The impact of probiotics on Helicobacter pylori eradication with bismuth quadruple therapy: A systematic review and meta-analysis.

International journal of antimicrobial agents · 2025 · PMID 40865583

Systematic ReviewMeta-AnalysisHuman subjects

“Adding probiotics, particularly S. boulardii or multi-strain combinations, to BQT significantly improves eradication efficacy and decreases treatment-related adverse events. PBQT represents a pragmatic optimization of current first-line regimens and supports its incorporation into clinical practice to improve H. pylori treatment outcomes.”

Liu et al. · Authors' conclusion

Names Amoxicillin and Saccharomyces Boulardii together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Amoxicillin, Saccharomyces Boulardii, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.