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Supplement × Prescription·Evidence index

Amoxicillin and Saccharomyces Boulardii: what the research found

PubMed indexes 8 records that name Amoxicillin and Saccharomyces Boulardii together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“Adding probiotics, particularly S. boulardii or multi-strain combinations, to BQT significantly improves eradication efficacy and decreases treatment-related adverse events. PBQT represents a pragmatic optimization of current first-line regimens and supports its incorporation into clinical practice to improve H. pylori treatment outcomes.”

Liu et al. · 2025 · Review or meta-analysis · details

“Supplementing vonoprazan-amoxicillin dual therapy with S. boulardii significantly increases H. pylori eradication rates and reduces adverse events, offering an effective and simple rescue treatment unaffected by previous treatment failures.”

Qu et al. · 2026 · Human study · details

“Addition of S. boulardii to VA-dual for 10 days is as effective as the 14-days bismuth-based quadruple regimen while ensuring fewer adverse events and lesser cost. This regimen is particularly suitable for low-BSA patients or non-smokers.”

The research

8 studies naming Amoxicillin and Saccharomyces Boulardii.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Vonoprazan-Amoxicillin Dual Therapy with or Without Saccharomyces boulardii Supplementation as a Rescue Regimen for Helicobacter pylori Infection.

Infection and drug resistance · 2026 · PMID 41971394

Case ReportsClinical Trial

“Supplementing vonoprazan-amoxicillin dual therapy with S. boulardii significantly increases H. pylori eradication rates and reduces adverse events, offering an effective and simple rescue treatment unaffected by previous treatment failures.”

Qu et al. · Authors' conclusion

Names both Amoxicillin and Saccharomyces Boulardii in its title.

Effectiveness and safety of vonoprazan and amoxicillin dual regimen with Saccharomyces boulardii supplements on eradication of Helicobacter pylori.

BMC gastroenterology · 2024 · PMID 39592940

Randomized Controlled Trial

“Addition of S. boulardii to VA-dual for 10 days is as effective as the 14-days bismuth-based quadruple regimen while ensuring fewer adverse events and lesser cost. This regimen is particularly suitable for low-BSA patients or non-smokers.”

Yu et al. · Authors' conclusion

Names both Amoxicillin and Saccharomyces Boulardii in its title.

Prospective randomized controlled study on the effects of Saccharomyces boulardii CNCM I-745 and amoxicillin-clavulanate or the combination on the gut microbiota of healthy volunteers.

Gut microbes · 2017 · PMID 27973989

Randomized Controlled TrialResearch Support, N.I.H., Extramural

“S. boulardii treatment can mitigate some antibiotic-induced microbiota changes (dysbiosis) and can also reduce antibiotic-associated diarrhea.”

Kabbani et al. · From the abstract

Names both Amoxicillin and Saccharomyces Boulardii in its title.

Vonoprazan-amoxicillin dual regimen with Saccharomyces boulardii as a rescue therapy for Helicobacter pylori: Current perspectives and implications.

World journal of gastroenterology · 2024 · PMID 38596495

EditorialHuman subjects

“boulardii comes in various formulations and dosages, warranting further exploration into the optimal dosage for supplementation in rescue therapy. Additionally, larger, randomized, double-blinded controlled trials are warranted to confirm these promising results.”

Dirjayanto et al. · From the abstract

Names both Amoxicillin and Saccharomyces Boulardii in its title.

The impact of probiotics on Helicobacter pylori eradication with bismuth quadruple therapy: A systematic review and meta-analysis.

International journal of antimicrobial agents · 2025 · PMID 40865583

Systematic ReviewMeta-AnalysisHuman subjects

“Adding probiotics, particularly S. boulardii or multi-strain combinations, to BQT significantly improves eradication efficacy and decreases treatment-related adverse events. PBQT represents a pragmatic optimization of current first-line regimens and supports its incorporation into clinical practice to improve H. pylori treatment outcomes.”

Liu et al. · Authors' conclusion

Names Amoxicillin and Saccharomyces Boulardii together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Amoxicillin, Saccharomyces Boulardii, and several hundred other substances.

Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.