NutriStack
Probiotics and Saccharomyces Boulardii, a synergy.
Adding the probiotic yeast Saccharomyces boulardii to bacterial probiotics broadens coverage and is particularly effective for preventing antibiotic-associated diarrhea.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Probiotics and Saccharomyces Boulardii
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Adding the probiotic yeast Saccharomyces boulardii to bacterial probiotics broadens coverage and is particularly effective for preventing antibiotic-associated diarrhea.
Mechanism. Bacterial probiotics competitively exclude pathogens and produce short-chain fatty acids, while S. boulardii is a yeast that survives antibiotic exposure, neutralizes bacterial toxins, and stimulates secretory IgA, so the two act through non-overlapping mechanisms.
Recommendation. Reasonable to combine. Unlike bacterial probiotics, S. boulardii is not killed by antibiotics, so it is a useful companion during antibiotic courses.
Sources (2)
- McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult patients. World Journal of Gastroenterology. 2010
- Hempel S, Newberry SJ, Maher AR, et al. Probiotics for the prevention and treatment of antibiotic-associated diarrhea: a systematic review and meta-analysis. JAMA. 2012
Stack Score
How this pair moves the number.
Effect on the composite score
If both Probiotics and Saccharomyces Boulardii are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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