From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
SynergyEmerging evidence
What is happening. Combining BB536 with other probiotic strains may broaden microbiome effects but can increase gas or make attribution difficult.
Mechanism. Different probiotic strains act through overlapping barrier, fermentation, and immune pathways.
Recommendation. Add one strain at a time and use products listing full strain IDs.
Stack Score
How it moves the number.
Effect on the composite score
If both Bifidobacterium longum BB536 and Probiotics are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Takii H et al. BB536 constipation RCT. American Journal of Gastroenterology. 2023.Needs sourceNo link