Supplement researchSourced from PubMed and NIH
NutriStack
Free iPhone appUpdated September 28, 2026

Supplement × Prescription·Evidence index

Azithromycin and Probiotics: what the research found

PubMed indexes 8 records that name Azithromycin and Probiotics together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.

A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.

Key findings

What the studies concluded.

Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.

“Probiotics have equal efficacy to azithromycin, and their combination has shown synergistic effects for the treatment of acne vulgaris. Probiotics should be used in combination with azithromycin for the best results for the management of acne vulgaris.”

Irshad et al. · 2023 · Human study · details

“These results suggested that probiotics prevent inflammation by affecting host responses rather than improving microbial flora in peri-implant sulci in peri-implantitis patients.”

Tada et al. · 2018 · Human study · details

“The use of probiotics or azithromycin as an adjunct to SRP failed to provide additional benefits in the treatment of stage III periodontitis. The benefits of these two treatment regimes as an adjunct to SRP remain unclear.”

The research

8 studies naming Azithromycin and Probiotics.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Comparative Effects of Azithromycin and Probiotics for Treatment of Acne Vulgaris.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP · 2023 · PMID 37190684

Human subjects

“Probiotics have equal efficacy to azithromycin, and their combination has shown synergistic effects for the treatment of acne vulgaris. Probiotics should be used in combination with azithromycin for the best results for the management of acne vulgaris.”

Irshad et al. · Authors' conclusion

Names both Azithromycin and Probiotics in its title.

Clinical effects of probiotic or azithromycin as an adjunct to scaling and root planning in the treatment of stage III periodontitis: a pilot randomized controlled clinical trial.

BMC oral health · 2021 · PMID 33413320

Randomized Controlled Trial

“The use of probiotics or azithromycin as an adjunct to SRP failed to provide additional benefits in the treatment of stage III periodontitis. The benefits of these two treatment regimes as an adjunct to SRP remain unclear.”

Morales et al. · Authors' conclusion

Names Azithromycin and Probiotics together in an interaction, co-administration, or pharmacokinetic context.

Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo- controlled trial with 9-month follow-up.

Journal of applied oral science : revista FOB · 2018 · PMID 29364340

Randomized Controlled Trial

“The adjunctive use of L. rhamnosus SP1 sachets and azithromycin during initial therapy resulted in similar clinical and microbiological improvements compared with the placebo group.”

Morales et al. · From the abstract

Names Azithromycin and Probiotics together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

How to read this page

A literature summary, not guidance.

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Azithromycin, Probiotics, and several hundred other substances.

Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.