From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Ashwagandha can be sedating in some people and may worsen azelastine-related drowsiness.
Mechanism. Additive CNS depressant effects in susceptible users.
Recommendation. Start one product at a time and avoid use before tasks requiring alertness if drowsy.
Stack Score
How it moves the number.
Effect on the composite score
If both Ashwagandha and Azelastine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Bousquet J et al. Allergic Rhinitis and its Impact on Asthma guidelines. Journal of Allergy and Clinical Immunology. 2020.Needs sourceNo link