From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
ConflictEmerging evidence
What is happening. Ashwagandha may have immune-stimulating effects and could conflict with immunosuppressive treatment goals in autoimmune disease or transplant.
Mechanism. Potential immunomodulatory effects may oppose therapeutic immunosuppression.
Recommendation. Avoid without clinician approval when azathioprine is used to prevent rejection or control autoimmune activity.
Stack Score
How it moves the number.
Effect on the composite score
If both Ashwagandha and Azathioprine are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Maltzman JS et al. Use of azathioprine in clinical medicine. Clinical Pharmacology and Therapeutics. 2011.Needs sourceNo link