Supplement × Prescription·a conflict·Emerging evidence

Ashwagandha + Azathioprine

Conflict Emerging evidence

Ashwagandha may have immune-stimulating effects and could conflict with immunosuppressive treatment goals in autoimmune disease or transplant.

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Pair type
Conflict
Evidence
Emerging
Source citations
1
Scope
Supplement × Prescription
Last verified
June 4, 2026
ConflictEmerging evidence

What is happening. Ashwagandha may have immune-stimulating effects and could conflict with immunosuppressive treatment goals in autoimmune disease or transplant.

Mechanism. Potential immunomodulatory effects may oppose therapeutic immunosuppression.

Recommendation. Avoid without clinician approval when azathioprine is used to prevent rejection or control autoimmune activity.

Stack Score

How it moves the number.

Effect on the composite score

If both Ashwagandha and Azathioprine are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Maltzman JS et al. Use of azathioprine in clinical medicine. Clinical Pharmacology and Therapeutics. 2011.Needs sourceNo link

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