From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Both can cause sedation, and both have rare liver-injury concerns in case reports.
Mechanism. Additive sedative burden and overlapping hepatic safety uncertainty.
Recommendation. Avoid high-dose or long-duration combination; stop for liver symptoms or unusual fatigue.
Stack Score
How it moves the number.
Effect on the composite score
If both Ashwagandha and Kava are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Teschke R et al. Kava hepatotoxicity clinical review. Ann Hepatol. 2010.Needs sourceNo link