Supplement × Supplement·a caution·Emerging evidence

Ashwagandha + Kava

Caution Emerging evidence

Both can cause sedation, and both have rare liver-injury concerns in case reports.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Caution
Evidence
Emerging
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
CautionEmerging evidence

What is happening. Both can cause sedation, and both have rare liver-injury concerns in case reports.

Mechanism. Additive sedative burden and overlapping hepatic safety uncertainty.

Recommendation. Avoid high-dose or long-duration combination; stop for liver symptoms or unusual fatigue.

Stack Score

How it moves the number.

Effect on the composite score

If both Ashwagandha and Kava are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Teschke R et al. Kava hepatotoxicity clinical review. Ann Hepatol. 2010.Needs sourceNo link

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