From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Ashwagandha can be sedating for some patients and may compound levetiracetam CNS effects.
Mechanism. Additive CNS effects and possible neuropsychiatric symptom overlap.
Recommendation. Use cautiously and monitor for sedation, mood changes, or irritability.
Stack Score
How it moves the number.
Effect on the composite score
If both Ashwagandha and Levetiracetam Extended-Release are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Mula M et al. Antiepileptic drugs and suicidality: an expert consensus statement. Epilepsia. 2013.Needs sourceNo link