From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. Ashwagandha can be sedating in some users and may add to antihistamine-related drowsiness.
Mechanism. Additive CNS depressant effects in susceptible patients.
Recommendation. Avoid starting high doses when assessing levocetirizine tolerability; stop if excessive sedation occurs.
Stack Score
How it moves the number.
Effect on the composite score
If both Ashwagandha and Levocetirizine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Bousquet J et al. Allergic Rhinitis and its Impact on Asthma guidelines. Journal of Allergy and Clinical Immunology. 2020.Needs sourceNo link