NutriStack
Aspirin Low-Dose and Lycopene, a caution.
Lycopene has antiplatelet activity in platelet studies, and an in vitro human platelet study directly evaluated lycopene with aspirin and found additive inhibition of platelet aggregation under test conditions. Direct clinical bleeding outcome data are lacking, but the combination is plausible enough to matter in people already at bleeding risk.
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At a glance
- Substances
- Aspirin Low-Dose and Lycopene
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Lycopene has antiplatelet activity in platelet studies, and an in vitro human platelet study directly evaluated lycopene with aspirin and found additive inhibition of platelet aggregation under test conditions. Direct clinical bleeding outcome data are lacking, but the combination is plausible enough to matter in people already at bleeding risk.
Mechanism. Aspirin irreversibly inhibits platelet cyclooxygenase and thromboxane-mediated aggregation. Lycopene has shown inhibition of platelet activation and aggregation pathways in vitro; together they may increase net antiplatelet effect.
Recommendation. Use lycopene supplements cautiously with low-dose aspirin, especially if you also take anticoagulants, clopidogrel, NSAIDs, SSRIs/SNRIs, or have a history of ulcers or bleeding. Keep doses stable and report easy bruising, nosebleeds, black stools, or prolonged bleeding. Do not stop prescribed aspirin without clinician guidance.
Sources (2)
- Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study. Indian J Pharmacol. 2016;48(1):26-31. PMID 26997718
- Hsiao G, Wang Y, Tzu NH, Fong TH, Shen MY, Lin KH, Chou DS, Sheu JR. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med. 2005;146(4):216-226. PMID 16194683
Stack Score
How this pair moves the number.
Effect on the composite score
If both Aspirin Low-Dose and Lycopene are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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