NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated July 13, 2026

Aspirin Low-Dose

Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026

Low-dose aspirin (75–100 mg) is an antiplatelet agent widely used for secondary prevention of cardiovascular events including myocardial infarction and ischemic stroke. Its role in primary prevention has been narrowed based on recent trials (ASPREE, ARRIVE, ASCEND) showing modest benefit with increased bleeding risk in low-risk populations.

Evidence tier
Strong
Indexed sources
13 2009–2025
Interactions
0
Category
Prescription
Read the sources → Compare profiles
Publication status

Exploratory record, not a reviewed medical publication.

See the editorial and medical-review policies for the publication gate.

This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.

In short

What the research says.

A quick, data-only summary. The full evidence, dosing, and sources are below.

Low-dose aspirin (75–100 mg) is an antiplatelet agent widely used for secondary prevention of cardiovascular events including myocardial infarction and ischemic stroke. NutriStack rates the supporting evidence as strong. Common adult dosing is 75–100 mg once daily for cardiovascular prevention (as prescribed by your physician), though a prescriber sets the actual dose. This profile indexes 13 sources.

What it's good for
  • Reduces risk of recurrent MI and stroke (secondary prevention)8,9
  • Essential in acute coronary syndromes
  • Required after coronary stent placement (with P2Y12 inhibitor)11
  • Inexpensive and widely available
What to watch for
  • GI bleeding and dyspepsia
  • Bruising
  • Epistaxis
  • Active GI bleeding or peptic ulcer5,6
  • Aspirin allergy or aspirin-exacerbated respiratory disease1,2

The bottom line

Evidence rating strong. Most-documented uses: reduces risk of recurrent mi and stroke (secondary prevention), essential in acute coronary syndromes, required after coronary stent placement (with p2y12 inhibitor). 13 sources indexed (2009–2025), with 0 interaction records on file.

The science

How it works, mechanistically.

Core mechanism

Irreversibly acetylates cyclooxygenase-1 (COX-1), blocking the formation of thromboxane A2 (TXA2), a potent platelet aggregator and vasoconstrictor. Since platelets lack nuclei and cannot synthesize new COX-1, the antiplatelet effect lasts the entire platelet lifespan (~7–10 days). Low doses selectively inhibit platelet COX-1 while relatively sparing endothelial COX-2/prostacyclin production.

Class
Antiplatelet Agent
Dosing

Dosing & protocol.

Common range
75–100 mg once daily for cardiovascular prevention (as prescribed by your physician)
Recommended form
Enteric-coated oral tablet (81 mg in the US)

Enteric-coated tablets may delay absorption; can be taken with food to reduce GI upset; chew non-enteric-coated tablet during suspected ACS for rapid onset1,2

Safety

Full safety detail.

Side effects

  • GI bleeding and dyspepsia
  • Bruising
  • Epistaxis
  • Tinnitus (at higher doses)
  • Gastric ulceration
  • Allergic reactions (aspirin-exacerbated respiratory disease)

Contraindications

  • Active GI bleeding or peptic ulcer5,6
  • Aspirin allergy or aspirin-exacerbated respiratory disease1,2
  • Bleeding disorders (severe thrombocytopenia, hemophilia)5,6
  • Children with viral illness (risk of Reye syndrome)
  • Third trimester of pregnancy1
Sources

Sources, by evidence tier.

Numbered references. Citations throughout the page link here.

Meta-analyses & systematic reviews

8

Reference material

5
FAQ

Common questions.

Quick answers about Aspirin Low-Dose, drawn from the data on this page.

What is Aspirin Low-Dose?

Low-dose aspirin (75–100 mg) is an antiplatelet agent widely used for secondary prevention of cardiovascular events including myocardial infarction and ischemic stroke. Its role in primary prevention has been narrowed based on recent trials (ASPREE, ARRIVE, ASCEND) showing modest benefit with increased bleeding risk in low-risk populations.

What is Aspirin Low-Dose used for?

Commonly cited benefits of Aspirin Low-Dose include: Reduces risk of recurrent MI and stroke (secondary prevention); Essential in acute coronary syndromes; Required after coronary stent placement (with P2Y12 inhibitor); Inexpensive and widely available. NutriStack rates the overall evidence as strong.

What is a typical dose of Aspirin Low-Dose?

A typical adult dose of Aspirin Low-Dose is 75–100 mg once daily for cardiovascular prevention (as prescribed by your physician). The commonly recommended form is Enteric-coated oral tablet (81 mg in the US). These are general ranges, not personalized advice; confirm the right dose with a clinician.

What are the side effects of Aspirin Low-Dose?

Reported side effects include gi bleeding and dyspepsia, bruising, epistaxis, tinnitus (at higher doses), gastric ulceration, allergic reactions (aspirin-exacerbated respiratory disease). This is educational information; check with a healthcare professional before use.

How strong is the evidence for Aspirin Low-Dose?

NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.

Use this with your stack

Aspirin Low-Dose in NutriStack.

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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.