NutriStack
Aspirin Low-Dose and Turmeric/Curcumin, a caution.
Turmeric/curcumin supplements may add antiplatelet effects to low-dose aspirin. Culinary turmeric is usually a minor exposure, but concentrated curcumin products can deliver much larger doses. The combination is most concerning with prior bleeding, upcoming procedures, high-dose curcumin, or additional blood-thinning medicines.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Aspirin Low-Dose and Turmeric/Curcumin
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Turmeric/curcumin supplements may add antiplatelet effects to low-dose aspirin. Culinary turmeric is usually a minor exposure, but concentrated curcumin products can deliver much larger doses. The combination is most concerning with prior bleeding, upcoming procedures, high-dose curcumin, or additional blood-thinning medicines.
Mechanism. Curcumin inhibits platelet aggregation pathways including thromboxane formation and calcium signaling. Aspirin irreversibly inhibits platelet COX-1, so concentrated curcumin can add pharmacodynamic antiplatelet activity.
Recommendation. Avoid high-dose turmeric/curcumin supplements with low-dose aspirin unless your clinician agrees. Stop curcumin before procedures if your surgical team recommends it, and report unusual bruising, nosebleeds, or black stools.
Sources (2)
- Shah BH, Nawaz Z, Pertani SA, Roomi A, Mahmood H, Saeed SA, et al. Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. Biochem Pharmacol. 1999;58(7):1167-1172. PMID 10484074
- Kaufman DW, Kelly JP, Wiholm BE, Laszlo A, Sheehan JE, Koff RS, et al. The risk of acute major upper gastrointestinal bleeding among users of aspirin and ibuprofen at various levels of alcohol consumption. Am J Gastroenterol. 1999;94(11):3189-3196. PMID 10566713
Stack Score
How this pair moves the number.
Effect on the composite score
If both Aspirin Low-Dose and Turmeric/Curcumin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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