NutriStack
Bacopa Monnieri and L-Theanine, a synergy.
Bacopa monnieri and L-theanine are commonly combined for cognitive support, with Bacopa supporting memory consolidation and L-theanine promoting calm focus, producing complementary effects without significant conflict.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Bacopa Monnieri and L-Theanine
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Bacopa monnieri and L-theanine are commonly combined for cognitive support, with Bacopa supporting memory consolidation and L-theanine promoting calm focus, producing complementary effects without significant conflict.
Mechanism. Bacopa modulates cholinergic signaling and antioxidant activity in the hippocampus, while L-theanine increases alpha brain wave activity and modulates GABA and glutamate, together supporting attention and reduced anxiety.
Recommendation. This combination is generally well tolerated. Start at standard individual doses and monitor for excess sedation or drowsiness.
Sources (2)
- Calabrese C, et al. Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. Journal of Alternative and Complementary Medicine, 2008.
- Nobre AC, Rao A, Owen GN. L-theanine, a natural constituent in tea, and its effect on mental state. Asia Pacific Journal of Clinical Nutrition, 2008.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Bacopa Monnieri and L-Theanine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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