NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Supplement·Evidence index

Green Tea Extract and L-Theanine: what the published research says

PubMed indexes 8 records that name Green Tea Extract and L-Theanine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Green Tea Extract and L-Theanine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

8 studies naming Green Tea Extract and L-Theanine.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Effects of Tea (Camellia sinensis) or its Bioactive Compounds l-Theanine or l-Theanine plus Caffeine on Cognition, Sleep, and Mood in Healthy Participants: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Nutrition reviews · 2025 · PMID 40314930

Systematic ReviewMeta-AnalysisHuman subjects

“This meta-analysis provides evidence that theanine plus caffeine, and theanine alone, could be beneficial for cognitive and mood outcomes. More research using tea beverages or tea-equivalent bioactive doses and research in free-living participants is needed.”

Payne et al. · Authors' conclusion

Names both Green Tea Extract and L-Theanine in its title.

Promoting L-theanine accumulation in Camellia sinensis through irrigation with Pseudomonas knackmussii.

Plant cell reports · 2025 · PMID 40658255

“Surprisingly, after irrigating the tea plants with a combination of endophytic bacteria and ethylamine, the L-theanine content of the third tea leaf was 131.7 mg/g dry weight after 14 days. This study reveals the significant potential of endophytic bacteria in tea plants to increase L-theanine content, providing empirical evidence for improving tea quality and demonstrating important theoretical and practical significance in tea production.”

Zhou et al. · From the abstract

Names both Green Tea Extract and L-Theanine in its title.

L-Theanine: A Unique Functional Amino Acid in Tea (Camellia sinensis L.) With Multiple Health Benefits and Food Applications.

Frontiers in nutrition · 2022 · PMID 35445053

Review

“Due to the unique characteristics and beneficial functions, L-theanine has potential applications in the development of functional foods. This review summarized the influencing factors of L-theanine content in teas, the main health benefits and related molecular mechanisms of L-theanine, and its applications in food, understanding of which can provide updated information for the further research of L-theanine.”

Li et al. · From the abstract

Names both Green Tea Extract and L-Theanine in its title.

L-theanine exuded from Camellia sinensis roots regulates element cycling in soil by shaping the rhizosphere microbiome assembly.

The Science of the total environment · 2022 · PMID 35561922

“Interestingly, the denitrification and complete nitrification pathways were significantly inhibited by L-theanine by decreasing the narH, napA, and napB genes abundance. These findings provide new insights into the biological function of L-theanine, as well as the implications of interactions between tea plant root exudates and the rhizosphere microbiome.”

Xie et al. · From the abstract

Names both Green Tea Extract and L-Theanine in its title.

Nutritional applications and beneficial health applications of green tea and l-theanine in some animal species: A review.

Journal of animal physiology and animal nutrition · 2020 · PMID 31595607

ReviewAnimal study

“Herein, an effort is made to extend the knowledge on the importance and useful applications of green tea and its important constituents in animal production including poultry. This review will be a guideline for researchers and entrepreneurs who want to explore the utilization of feeds supplemented with green tea and green tea by-products for the enhancement of livestock production.”

Alagawany et al. · From the abstract

Names both Green Tea Extract and L-Theanine in its title.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Green Tea Extract, L-Theanine, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.