NutriStack
Atorvastatin and Green Tea Extract, a conflict.
Green tea extract reduced atorvastatin peak concentration and overall exposure in a human crossover study. The effect appears related to reduced absorption rather than faster elimination, and could matter if LDL control is marginal. Brewed green tea is likely less concerning than concentrated extract capsules.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Atorvastatin and Green Tea Extract
- Pair type
- Conflict
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −10 to your Stack Score (per scored conflict row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Conflict · Moderate evidence
Conflict
What is happening. Green tea extract reduced atorvastatin peak concentration and overall exposure in a human crossover study. The effect appears related to reduced absorption rather than faster elimination, and could matter if LDL control is marginal. Brewed green tea is likely less concerning than concentrated extract capsules.
Mechanism. Green tea catechins can inhibit intestinal uptake transporters such as OATPs involved in drug absorption. In healthy volunteers, green tea extract lowered atorvastatin Cmax by about one quarter and AUC by about one fifth.
Recommendation. Avoid taking concentrated green tea extract at the same time as atorvastatin. If you use green tea extract regularly, keep the routine consistent and recheck lipids after starting or stopping it.
Sources (2)
- Abdelkawy KS, Abdelaziz RM, Abdelmageed AM, Donia AM, El-Khodary NM. Effects of Green Tea Extract on Atorvastatin Pharmacokinetics in Healthy Volunteers. Eur J Drug Metab Pharmacokinet. 2020;45(3):351-360. PMID 31997084
- Werba JP, Misaka S, Giroli MG, Yamada S, Cavalca V, Kawabe K, et al. Overview of green tea interaction with cardiovascular drugs. Curr Pharm Des. 2015;21(9):1213-1219. PMID 25312732
Stack Score
How this pair moves the number.
Effect on the composite score
If both Atorvastatin and Green Tea Extract are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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