Regulatory effect of atorvastatin combined with berberine on PI3K/AKT/FoxO1 signaling pathway in rats with hyperlipidaemia.
Animal study
Names both Atorvastatin and Berberine in its title.
Supplement × Prescription·Evidence index
PubMed indexes 4 records that name Atorvastatin and Berberine together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.
Every statement below is attributed to a named, dated, linked source.
This page lists published research relevant to Atorvastatin and Berberine. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
Names both Atorvastatin and Berberine in its title.
Names both Atorvastatin and Berberine in its title.
“Moreover, it could be found that there is a significant recovery in liver histopathology.In conclusion, berberine could affect pharmacokinetics of atorvastatin, enhance lipid-lowering effect and improve liver injury in rats. More attention should be paid to plasma exposure in clinical to avoid adverse reactions.”
Names both Atorvastatin and Berberine in its title.
“Furthermore, plasma ET‑1 levels and LOX‑1 expression were decreased by berberine combined with atorvastatin treatment, and the inhibitory effect on LOX‑1 was impeded by an ET‑1 receptor antagonist. The results demonstrated that berberine combined with atorvastatin downregulates LOX‑1 expression through ET‑1 receptors in monocyte/macrophages in vitro and in vivo.”
Names both Atorvastatin and Berberine in its title.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Atorvastatin, Berberine, and several hundred other substances.
The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.