Supplement × Supplement·a synergy·Moderate evidence

Caffeine + L-Theanine

Synergy Moderate evidence

Theanine may smooth caffeine-related jitteriness while preserving attention benefits.

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances
Pair type
Synergy
Evidence
Moderate
Source citations
1
Scope
Supplement × Supplement
Last verified
June 4, 2026
SynergyModerate evidence

What is happening. Theanine may smooth caffeine-related jitteriness while preserving attention benefits.

Mechanism. Caffeine increases arousal while theanine modulates glutamate and alpha-wave activity.

Recommendation. Common pairing at moderate doses, such as 100 mg caffeine with 200 mg theanine.

Stack Score

How it moves the number.

Effect on the composite score

If both Caffeine and L-Theanine are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1
  • 1Guest NS et al. ISSN caffeine position stand. JISSN. 2021.Needs sourceNo link

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