NutriStack
Berberine and Dapagliflozin, a caution.
Dapagliflozin and berberine both lower blood glucose through independent mechanisms. Combined use may increase hypoglycemia risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
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At a glance
- Substances
- Berberine and Dapagliflozin
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Dapagliflozin and berberine both lower blood glucose through independent mechanisms. Combined use may increase hypoglycemia risk.
Mechanism. Dapagliflozin inhibits SGLT2 in the proximal tubule, causing urinary glucose excretion. Berberine activates AMPK. Both lower glucose through insulin-independent mechanisms.
Recommendation. Monitor blood glucose when combining. Low risk when used alone but relevant in multi-drug regimens.
Sources (2)
- McMurray JJV et al. Dapagliflozin in patients with heart failure (DAPA-HF). N Engl J Med. 2019;381(21):1995-2008. PMID 31535829
- Asbaghi O, Ghanbari N, Shekari M et al.. The effect of berberine supplementation on obesity parameters, inflammation and liver function enzymes: A systematic review and meta-analysis of randomized controlled trials.. Clinical Nutrition ESPEN. 2020. PMID 32690176
Stack Score
How this pair moves the number.
Effect on the composite score
If both Berberine and Dapagliflozin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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