What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Amlodipine + Berberine pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Amlodipine and Berberine, a caution.

Q: Can I take Amlodipine and Berberine together?

Possibly, but with caution. Amlodipine and Berberine have a documented caution-tier interaction. Berberine is a clinically demonstrated inhibitor of CYP3A4, the main enzyme that clears amlodipine. Co-administration can raise amlodipine plasma levels and prolong its half-life, increasing the risk of excessive blood pressure lowering, peripheral edema, dizziness, and reflex tachycardia. The effect builds over days because berberine accumulates with repeated dosing.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Berberine is a clinically demonstrated inhibitor of CYP3A4, the main enzyme that clears amlodipine. Co-administration can raise amlodipine plasma levels and prolong its half-life, increasing the risk of excessive blood pressure lowering, peripheral edema, dizziness, and reflex tachycardia. The effect builds over days because berberine accumulates with repeated dosing.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Amlodipine and Berberine
Pair type: Caution
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Moderate evidence

Caution

What is happening. Berberine is a clinically demonstrated inhibitor of CYP3A4, the main enzyme that clears amlodipine. Co-administration can raise amlodipine plasma levels and prolong its half-life, increasing the risk of excessive blood pressure lowering, peripheral edema, dizziness, and reflex tachycardia. The effect builds over days because berberine accumulates with repeated dosing.

Mechanism. Repeated berberine dosing in humans reduces CYP3A4 (and CYP2D6, CYP2C9) activity, slowing oxidative metabolism of amlodipine. Rat data also show inhibition of intestinal P-gp, which can further raise oral bioavailability.

Recommendation. Avoid pairing berberine with amlodipine unless your prescriber agrees, and if you do, separate doses by at least 4 hours and monitor your blood pressure for 1-2 weeks. Reduce or stop berberine if your readings fall below your usual range, or you develop new lightheadedness or swelling.

Minimum separation. 240

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Amlodipine and Berberine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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