NutriStack
Amlodipine and L-Citrulline, a caution.
L-Citrulline is converted to L-arginine and raises plasma arginine more efficiently than oral arginine itself, producing nitric-oxide-mediated vasodilation. Stacked on top of amlodipine's calcium channel blockade, this can drop blood pressure further than intended, with dizziness, fatigue, or headache.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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From the interaction database
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At a glance
- Substances
- Amlodipine and L-Citrulline
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. L-Citrulline is converted to L-arginine and raises plasma arginine more efficiently than oral arginine itself, producing nitric-oxide-mediated vasodilation. Stacked on top of amlodipine's calcium channel blockade, this can drop blood pressure further than intended, with dizziness, fatigue, or headache.
Mechanism. L-Citrulline bypasses hepatic first-pass metabolism, raises systemic arginine, and increases eNOS substrate availability. The resulting vasodilation adds to amlodipine's hypotensive effect.
Recommendation. If you take amlodipine, start L-citrulline at lower doses (3 g/day or less) and track blood pressure for 1-2 weeks. Reduce the dose or stop if you become lightheaded or your readings fall below your usual range.
Sources (2)
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials. Curr Hypertens Rep. 2018;20(11):98. PMID 30284051
- Dong JY, Qin LQ, Zhang Z, et al. Effect of oral L-arginine supplementation on blood pressure: a meta-analysis of randomized, double-blind, placebo-controlled trials. Am Heart J. 2011;162(6):959-65. PMID 22137067
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amlodipine and L-Citrulline are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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