What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Chlorthalidone + L-Citrulline pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Chlorthalidone and L-Citrulline, a caution.

Q: Can I take Chlorthalidone and L-Citrulline together?

Possibly, but with caution. Chlorthalidone and L-Citrulline have a documented caution-tier interaction. L-Citrulline can modestly lower blood pressure through the arginine-nitric oxide pathway. Chlorthalidone has sustained antihypertensive and diuretic effects, so adding L-Citrulline can increase the chance of symptomatic low blood pressure. Dehydration, low sodium, older age, and multi-drug blood-pressure therapy increase risk.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

L-Citrulline can modestly lower blood pressure through the arginine-nitric oxide pathway. Chlorthalidone has sustained antihypertensive and diuretic effects, so adding L-Citrulline can increase the chance of symptomatic low blood pressure. Dehydration, low sodium, older age, and multi-drug blood-pressure therapy increase risk.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Chlorthalidone and L-Citrulline
Pair type: Caution
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Moderate evidence

Caution

What is happening. L-Citrulline can modestly lower blood pressure through the arginine-nitric oxide pathway. Chlorthalidone has sustained antihypertensive and diuretic effects, so adding L-Citrulline can increase the chance of symptomatic low blood pressure. Dehydration, low sodium, older age, and multi-drug blood-pressure therapy increase risk.

Mechanism. L-Citrulline raises systemic arginine availability and supports nitric oxide-mediated vasodilation. Chlorthalidone reduces blood pressure through sodium loss and vascular adaptation, making additive blood-pressure lowering possible.

Recommendation. If you use L-Citrulline with chlorthalidone, begin with a low dose and check blood pressure at home. Reduce or stop it if you develop dizziness, fainting, or readings below your usual range, and discuss persistent symptoms with your prescriber.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Chlorthalidone and L-Citrulline are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

Check your full routine

One pair was the worked example. NutriStack runs every pair in your stack at once.

Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.

Open the interaction checker →Browse the full research index