NutriStack
Alfuzosin and L-Citrulline, a caution.
L-Citrulline increases systemic arginine availability and can modestly lower blood pressure. Alfuzosin can also contribute to blood-pressure symptoms, especially when combined with other agents that lower vascular tone. Together they may cause dizziness, fatigue, or near-fainting.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Alfuzosin and L-Citrulline
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. L-Citrulline increases systemic arginine availability and can modestly lower blood pressure. Alfuzosin can also contribute to blood-pressure symptoms, especially when combined with other agents that lower vascular tone. Together they may cause dizziness, fatigue, or near-fainting.
Mechanism. L-Citrulline is converted to L-arginine and increases nitric-oxide-mediated vasodilation. Alfuzosin blocks alpha1-mediated smooth muscle tone, creating additive potential for lower systemic vascular resistance.
Recommendation. Do not start L-citrulline and alfuzosin on the same day if you can avoid it. If using both, begin with a low L-citrulline dose, track blood pressure, and stop or reduce it if you become lightheaded.
Sources (2)
- Zhang LT, Lee SW, Park K, Chung WS, Kim SW, Hyun JS, Moon DG, Yang SK. Multicenter, prospective, comparative cohort study evaluating the efficacy and safety of alfuzosin 10 mg with regard to blood pressure in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia with or without antihypertensive medications. Clin Interv Aging. 2015;10:277-286. PMID 25653511
- Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials. Curr Hypertens Rep. 2018;20(11):98. PMID 30284051
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alfuzosin and L-Citrulline are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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