Alfuzosin
Prescription ·Exploratory record · not publication-reviewed ·Updated July 13, 2026
Alfuzosin is an alpha-1 adrenergic receptor antagonist with relative selectivity for the lower urinary tract, used for the treatment of signs and symptoms of benign prostatic hyperplasia (BPH). It provides effective relief of LUTS with a low incidence of ejaculatory dysfunction compared to tamsulosin, making it a preferred option for sexually active men.
Exploratory record, not a reviewed medical publication.
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This generated database record has not completed a claim-level review by a qualified human medical reviewer. Bibliography links and evidence labels are not approval. The page remains available for reference and is excluded from search indexing.
What the research says.
A quick, data-only summary. The full evidence, dosing, and sources are below.
Alfuzosin is an alpha-1 adrenergic receptor antagonist with relative selectivity for the lower urinary tract, used for the treatment of signs and symptoms of benign prostatic hyperplasia (BPH). NutriStack rates the supporting evidence as strong. Common adult dosing is 10 mg once daily immediately after the same meal each day (as prescribed by your physician), though a prescriber sets the actual dose. This profile indexes 10 sources.
The bottom line
Evidence rating strong. Most-documented uses: effective bph symptom relief (ipss score improvement), lower incidence of ejaculatory dysfunction compared to tamsulosin, once-daily extended-release dosing. 10 sources indexed (2001–2026), with 0 interaction records on file.
How it works, mechanistically.
Core mechanism
Blocks alpha-1 adrenergic receptors in the smooth muscle of the prostate, prostatic capsule, and bladder trigone/neck. Although not as subtype-selective as tamsulosin, alfuzosin demonstrates relative uroselectivity in clinical practice, reducing urethral resistance and improving urinary flow rate with modest effects on blood pressure.5
Dosing & protocol.
Must be taken immediately after a meal; bioavailability decreases by approximately 50% under fasting conditions. Do not crush, chew, or split extended-release tablets.
Full safety detail.
Side effects
- Dizziness
- Upper respiratory tract infection
- Headache
- Fatigue
- Orthostatic hypotension
- Intraoperative floppy iris syndrome (IFIS)
Contraindications
Sources, by evidence tier.
Numbered references. Citations throughout the page link here.
Meta-analyses & systematic reviews
2- 1Alfuzosin for the medical treatment of benign prostatic hyperplasia and lower urinary tract symptoms: a systematic review of the literature and narrative synthesisPMIDMari A, Antonelli A, Cindolo L et al. · Therapeutic advances in urology · 2021
Mari A, Antonelli A, Cindolo L et al.. Alfuzosin for the medical treatment of benign prostatic hyperplasia and lower urinary tract symptoms: a systematic review of the literature and narrative synthesis. Therapeutic advances in urology. 2021
- 2Efficacy and Safety of Alfuzosin as Medical Expulsive Therapy for Ureteral Stones: A Systematic Review and Meta-AnalysisPMIDLiu C, Zeng G, Kang R et al. · PloS one · 2015
Liu C, Zeng G, Kang R et al.. Efficacy and Safety of Alfuzosin as Medical Expulsive Therapy for Ureteral Stones: A Systematic Review and Meta-Analysis. PloS one. 2015
Randomized controlled trials
2- 3Efficacy of Serenoa repens Extract Combined With Alfuzosin Versus Alfuzosin Alone in Men With Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: A Multicenter Randomized StudyPMIDBevilacqua G, Carino D, Salciccia S et al. · The Prostate · 2026
Bevilacqua G, Carino D, Salciccia S et al.. Efficacy of Serenoa repens Extract Combined With Alfuzosin Versus Alfuzosin Alone in Men With Lower Urinary Tract Symptoms Due to Benign Prostatic Hyperplasia: A Multicenter Randomized Study. The Prostate. 2026
- 4Alfuzosin to relieve ureteral stent discomfort: a prospective, randomized, placebo controlled studyPMIDBeddingfield R, Pedro RN, Hinck B et al. · The Journal of urology · 2009
Beddingfield R, Pedro RN, Hinck B et al.. Alfuzosin to relieve ureteral stent discomfort: a prospective, randomized, placebo controlled study. The Journal of urology. 2009
Reviews & position papers
1- 5Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blockerPMIDRoehrborn CG · Urology · 2001
Roehrborn CG. Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blocker. Urology. 2001
Reference material
5- 6MacDonald R, Wilt TJ. Alfuzosin for treatment of lower urinary tract symptoms compatible with benign prostatic hyperplasia: a systematic review of efficacy and adverse effects. Urology. 2005;66(4):780-788.Source linkedPMID
- 7van Kerrebroeck P et al. Efficacy and safety of a new prolonged release formulation of alfuzosin 10 mg once daily versus alfuzosin 2.5 mg thrice daily and placebo in patients with symptomatic BPH. Eur Urol. 2000;37(3):306-313.Source linkedPMID
- 8Roehrborn CG. Alfuzosin 10 mg once daily prevents overall clinical progression of benign prostatic hyperplasia but not acute urinary retention: results of a 2-year placebo-controlled study. BJU Int. 2006;97(4):734-741.Source linkedPMID
- 9Yeung HEL, Sena SJ, Calopedos RJ et al.. Alfuzosin and Its Effect on Ejaculatory Dysfunction: A Systematic Review. The world journal of men's health. 2021Source linkedPMID
- 10Kuritzky L, Rosenberg MT, Sadovsky R. Efficacy and safety of alfuzosin 10 mg once daily in the treatment of symptomatic benign prostatic hyperplasia. International journal of clinical practice. 2006Source linkedPMID
Common questions.
Quick answers about Alfuzosin, drawn from the data on this page.
What is Alfuzosin?
Alfuzosin is an alpha-1 adrenergic receptor antagonist with relative selectivity for the lower urinary tract, used for the treatment of signs and symptoms of benign prostatic hyperplasia (BPH). It provides effective relief of LUTS with a low incidence of ejaculatory dysfunction compared to tamsulosin, making it a preferred option for sexually active men.
What is Alfuzosin used for?
Commonly cited benefits of Alfuzosin include: Effective BPH symptom relief (IPSS score improvement); Lower incidence of ejaculatory dysfunction compared to tamsulosin; Once-daily extended-release dosing; Well-established safety profile. NutriStack rates the overall evidence as strong.
What is a typical dose of Alfuzosin?
A typical adult dose of Alfuzosin is 10 mg once daily immediately after the same meal each day (as prescribed by your physician). The commonly recommended form is Extended-release tablet (10 mg). These are general ranges, not personalized advice; confirm the right dose with a clinician.
What are the side effects of Alfuzosin?
Reported side effects include dizziness, upper respiratory tract infection, headache, fatigue, orthostatic hypotension, intraoperative floppy iris syndrome (ifis). This is educational information; check with a healthcare professional before use.
How strong is the evidence for Alfuzosin?
NutriStack rates this as Strong, meaning multiple high-quality meta-analyses or systematic reviews converge on the same finding. Full tier criteria are at https://nutristackapp.com/methodology/evidence-tiers.
Use this with your stack
Alfuzosin in NutriStack.
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