NutriStack
Alfuzosin and Pine Bark Extract, a caution.
Alfuzosin is used for LUTS/BPH and can contribute to blood-pressure symptoms in susceptible patients, particularly with other agents that lower vascular tone. Pine bark extract has shown modest reductions in systolic and diastolic blood pressure in some randomized-trial meta-analyses. The combination may increase lightheadedness, fatigue, or near-syncope in patients with low baseline pressure or concurrent antihypertensive therapy.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Alfuzosin and Pine Bark Extract
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Alfuzosin is used for LUTS/BPH and can contribute to blood-pressure symptoms in susceptible patients, particularly with other agents that lower vascular tone. Pine bark extract has shown modest reductions in systolic and diastolic blood pressure in some randomized-trial meta-analyses. The combination may increase lightheadedness, fatigue, or near-syncope in patients with low baseline pressure or concurrent antihypertensive therapy.
Mechanism. Alfuzosin blocks alpha1 receptors and can reduce vascular resistance. Pine bark extract may enhance endothelial vasodilatory signaling and modestly lower blood pressure, so the combination can reduce compensatory vascular tone.
Recommendation. Start pine bark extract cautiously if you take alfuzosin. Monitor blood pressure and orthostatic symptoms during the first 1-2 weeks, and stop or reduce the supplement if readings drop below your usual range or you feel faint.
Sources (2)
- Zhang LT, Lee SW, Park K, Chung WS, Kim SW, Hyun JS, Moon DG, Yang SK. Multicenter, prospective, comparative cohort study evaluating the efficacy and safety of alfuzosin 10 mg with regard to blood pressure in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia with or without antihypertensive medications. Clin Interv Aging. 2015;10:277-286. PMID 25653511
- Malekahmadi M, Moradi Moghaddam O, Firouzi S, Daryabeygi-Khotbehsara R, Islam SMS, Norouzy A, Soltani S. Effects of pycnogenol on cardiometabolic health: A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 2019;150:104472. PMID 31585179
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alfuzosin and Pine Bark Extract are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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