NutriStack
Amlodipine and Garlic Extract, a caution.
Aged garlic extract reduces systolic and diastolic blood pressure by about 8 and 5 mmHg in hypertensive patients in meta-analysis. Added on top of amlodipine, the additive antihypertensive effect can be welcome but can also produce dizziness or symptomatic hypotension in patients already at goal blood pressure.
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At a glance
- Substances
- Amlodipine and Garlic Extract
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Aged garlic extract reduces systolic and diastolic blood pressure by about 8 and 5 mmHg in hypertensive patients in meta-analysis. Added on top of amlodipine, the additive antihypertensive effect can be welcome but can also produce dizziness or symptomatic hypotension in patients already at goal blood pressure.
Mechanism. Garlic (S-allyl cysteine and other organosulfur compounds) increases endothelial nitric oxide, reduces angiotensin-converting enzyme activity, and modestly vasodilates. These effects add to amlodipine's calcium channel blockade.
Recommendation. If you take amlodipine, monitor your blood pressure for 2-4 weeks after starting garlic extract. If readings drop below your usual range or you become lightheaded, reduce the garlic dose or talk with your prescriber about lowering amlodipine.
Sources (2)
- Ried K. Garlic lowers blood pressure in hypertensive subjects, improves arterial stiffness and gut microbiota: A review and meta-analysis. Exp Ther Med. 2020;19(2):1472-1478. PMID 32010325
- Bailey DG, Malcolm J, Arnold O, Spence JD. Grapefruit juice-drug interactions. Br J Clin Pharmacol. 1998;46(2):101-10. PMID 9723817
Stack Score
How this pair moves the number.
Effect on the composite score
If both Amlodipine and Garlic Extract are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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