NutriStack
Berberine HCl and Cyclosporine/Tacrolimus, contraindicated.
Berberine inhibits CYP3A4 and P-glycoprotein, increasing cyclosporine AUC by 34.5% and prolonging half-life by 2.7 hours in renal transplant recipients.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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At a glance
- Substances
- Berberine HCl and Cyclosporine/Tacrolimus
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 2 sources
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. Berberine inhibits CYP3A4 and P-glycoprotein, increasing cyclosporine AUC by 34.5% and prolonging half-life by 2.7 hours in renal transplant recipients.
Mechanism. Berberine inhibits intestinal P-glycoprotein efflux and hepatic CYP3A4 metabolism of cyclosporine/tacrolimus.
Recommendation. Do NOT combine without transplant specialist supervision. May require immunosuppressant dose reduction.
Sources (2)
Stack Score
How this pair moves the number.
Effect on the composite score
If both Berberine HCl and Cyclosporine/Tacrolimus are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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