NutriStack
Carbamazepine and Methylfolate, a synergy.
Carbamazepine depletes folate through enzyme induction effects on folate metabolism. Folate deficiency during carbamazepine therapy can cause megaloblastic anemia and is particularly concerning in women of childbearing age due to increased neural tube defect risk during pregnancy.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Carbamazepine and Methylfolate
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Carbamazepine depletes folate through enzyme induction effects on folate metabolism. Folate deficiency during carbamazepine therapy can cause megaloblastic anemia and is particularly concerning in women of childbearing age due to increased neural tube defect risk during pregnancy.
Mechanism. Carbamazepine induces hepatic enzymes that increase folate catabolism and may also impair intestinal folate absorption. The net effect is reduced serum and red cell folate levels, which can lead to megaloblastic changes and hyperhomocysteinemia over time.
Recommendation. Supplement with folic acid (1mg/day) during carbamazepine therapy, particularly for women of childbearing age. Higher doses (4mg/day) are recommended periconceptionally for women on antiepileptic drugs.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Carbamazepine and Methylfolate are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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