What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Cholestyramine + Vitamin B6 pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Supplement × Prescription·timing-sensitive·Moderate evidence

Cholestyramine + Vitamin B6

Q: Can I take Cholestyramine and Vitamin B6 together?

Yes, if you separate them in time. Cholestyramine and Vitamin B6 have a documented timing-sensitive interaction. Cholestyramine can bind and reduce intestinal absorption of folate, and folate deficiency has been documented with prolonged therapy, especially in children. While this primarily affects folate, taking other supplements at the same time as the resin also risks reduced absorption.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Timing Sensitive Moderate evidence

Cholestyramine can bind and reduce intestinal absorption of folate, and folate deficiency has been documented with prolonged therapy, especially in children. While this primarily affects folate, taking other supplements at the same time as the resin also risks reduced absorption.

Supplement × Prescription

Open the interaction checker → Read the methodology

From the database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, and the recommendation.

Substances

Cholestyramine and Vitamin B6

Pair type

Timing Sensitive

Evidence

Moderate

Source citations

Scope

Supplement × Prescription

Last verified

June 4, 2026

Timing SensitiveModerate evidence

What is happening. Cholestyramine can bind and reduce intestinal absorption of folate, and folate deficiency has been documented with prolonged therapy, especially in children. While this primarily affects folate, taking other supplements at the same time as the resin also risks reduced absorption.

Mechanism. The anion-exchange resin physically binds folate and other negatively charged or polar molecules in the gut lumen, reducing their absorption.

Recommendation. Administer folate and B-vitamin supplements separately from cholestyramine, ideally at least 1 hour before or 4 to 6 hours after. Monitor folate status during long-term therapy, particularly in children and pregnant patients.

Timing

Timing & separation.

Space the doses apart by at least this window to avoid the conflict.

Minimum separation

240

Stack Score

How it moves the number.

Effect on the composite score

If both Cholestyramine and Vitamin B6 are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.

Sources

Sources, by evidence tier.

Every claim on this page is cited. PMIDs link straight to PubMed.

Reference material

1West RJ, Lloyd JK. Effect of cholestyramine on intestinal absorption of folate. Arch Dis Child. 1975.Needs sourceNo link
2Questran (cholestyramine) US prescribing information. Drug interactions: folic acid and other agents.Needs sourceNo link

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Open the interaction checker → Browse the research index