What kind of interaction is it?

Timing-sensitive: the two substances can be taken on the same day but should be separated by a minimum time window.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Chromium + Levothyroxine pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Chromium and Levothyroxine, timing-sensitive.

Q: Can I take Chromium and Levothyroxine together?

Yes, if you separate them in time. Chromium and Levothyroxine have a documented timing-sensitive interaction. Chromium supplements, particularly chromium picolinate, have been shown in a small human absorption study to reduce levothyroxine exposure. This can make levothyroxine less effective if the two are taken together. The interaction is not usually dangerous when doses are separated, but it can matter for people with tight TSH targets.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored timing-sensitive row.

Chromium supplements, particularly chromium picolinate, have been shown in a small human absorption study to reduce levothyroxine exposure. This can make levothyroxine less effective if the two are taken together. The interaction is not usually dangerous when doses are separated, but it can matter for people with tight TSH targets.

2 primary source citations. Moderate evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Chromium and Levothyroxine
Pair type: Timing Sensitive
Evidence (highest tier): Moderate
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored timing-sensitive row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Timing Sensitive · Moderate evidence

Timing Sensitive

What is happening. Chromium supplements, particularly chromium picolinate, have been shown in a small human absorption study to reduce levothyroxine exposure. This can make levothyroxine less effective if the two are taken together. The interaction is not usually dangerous when doses are separated, but it can matter for people with tight TSH targets.

Mechanism. Chromium picolinate appears to reduce the area under the thyroxine concentration curve after oral levothyroxine, likely through intestinal binding or impaired dissolution. The result is lower bioavailability rather than altered thyroid hormone metabolism.

Recommendation. Take levothyroxine at least 4 hours apart from chromium supplements. Recheck thyroid labs after starting or stopping regular chromium use, especially if symptoms change.

Minimum separation. 240

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Chromium and Levothyroxine are in the same stack, this pair applies −5 to your Stack Score (per scored timing-sensitive row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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