NutriStack
DIM and Levothyroxine, a caution.
DIM (diindolylmethane) may affect thyroid hormone metabolism by inducing phase II conjugation enzymes. It can alter the estrogen-thyroid axis interaction and may increase levothyroxine clearance in some individuals.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- DIM and Levothyroxine
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 4 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. DIM (diindolylmethane) may affect thyroid hormone metabolism by inducing phase II conjugation enzymes. It can alter the estrogen-thyroid axis interaction and may increase levothyroxine clearance in some individuals.
Mechanism. DIM induces UGT and sulfotransferase enzymes that participate in thyroid hormone conjugation. It also modulates estrogen metabolism, which can indirectly affect thyroxine-binding globulin levels.
Recommendation. Monitor TSH levels when starting DIM supplementation on levothyroxine. Dose adjustment may be needed. Take DIM at least 4 hours after levothyroxine.
Minimum separation. 240
Sources (4)
- Rajoria S et al. 3,3'-diindolylmethane modulates estrogen metabolism in patients with thyroid proliferative disease. Thyroid. 2011;21(3):299-304. PMID 21254914
- Ross DS. Treating hypothyroidism is not always easy: When to treat subclinical hypothyroidism, TSH goals in the elderly, and alternatives to levothyroxine monotherapy. Journal of Internal Medicine. 2022. PMID 34766382
- Yerushalmi R, Bargil S, Ber Y, Ozlavo R, Sivan T, Rapson Y et al.. 3,3-Diindolylmethane (DIM): a nutritional intervention and its impact on breast density in healthy BRCA carriers. A prospective clinical trial.. Carcinogenesis. 2020. PMID 32458980
- Godnez-Martnez E, Santilln R, Smano R, Chico-Barba G, Tolentino MC, Hernndez-Pineda J. Effectiveness of 3,3'-Diindolylmethane Supplements on Favoring the Benign Estrogen Metabolism Pathway and Decreasing Body Fat in Premenopausal Women.. Nutrition and Cancer. 2023. PMID 36111381
Stack Score
How this pair moves the number.
Effect on the composite score
If both DIM and Levothyroxine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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