NutriStack
Citalopram and St. John's Wort, contraindicated.
Dual serotonin reuptake inhibition from citalopram and St. John's Wort creates serotonin syndrome risk.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Citalopram and St. John's Wort
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. Dual serotonin reuptake inhibition from citalopram and St. John's Wort creates serotonin syndrome risk.
Mechanism. Both agents block SERT. Combined blockade leads to excessive synaptic serotonin. Additionally, SJW may alter citalopram levels through CYP enzyme induction.
Recommendation. Do NOT combine St. John's Wort with citalopram.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Citalopram and St. John's Wort are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
Check your full routine
One pair was the worked example. NutriStack runs every pair in your stack at once.
Drop in your supplements and prescriptions and the public database surfaces every interaction, synergy, timing rule, and contraindication, every one linked to its primary source.