From the databaseWhat the row says.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
Scope
Supplement × Prescription
Last verified
June 4, 2026
CautionEmerging evidence
What is happening. L-Theanine may add to clonidine-related sedation or blood pressure lowering.
Mechanism. Additive calming or hypotensive effects may occur.
Recommendation. Use cautiously and avoid combining with alcohol or other sedatives unless clinician-reviewed.
Stack Score
How it moves the number.
Effect on the composite score
If both Clonidine and L-Theanine are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
SourcesSources, by evidence tier.
Every claim on this page is cited. PMIDs link straight to PubMed.
Reference material
1- 1Natural Medicines sedative supplement interaction reviews.Needs sourceNo link