Supplement × Prescription·Evidence index
PubMed indexes 8 records that name Clonidine and Melatonin together, either in the title or in an interaction, co-administration, or pharmacokinetic context. The key findings come first, in the authors’ own words, followed by every study with its design and PubMed link.
A summary of published research, not medical advice. A pharmacist can check any combination against your full list of medicines and supplements.
Reviews and human studies first. Each quote is the authors’ own conclusion about their study, not a NutriStack assessment, and a single study is not a consensus.
“Notably, the incidence of adverse effects did not differ significantly among the three groups. CONCLUSION: The findings of the present study indicate that both clonidine and melatonin are effective treatments for sleep disturbances in children with anxiety disorders.”
“Melatonin was effective for steal induction in 75% of children compared to 88% of children who had clonidine. Melatonin resulted less effective when administered early in the morning.”
“The preoperative anxiolysis with melatonin or clonidine reduced postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy. The effects these 2 drugs were equivalent and greater than with placebo.”
Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.
“Notably, the incidence of adverse effects did not differ significantly among the three groups. CONCLUSION: The findings of the present study indicate that both clonidine and melatonin are effective treatments for sleep disturbances in children with anxiety disorders.”
Names both Clonidine and Melatonin in its title.
Names both Clonidine and Melatonin in its title.
“Melatonin was effective for steal induction in 75% of children compared to 88% of children who had clonidine. Melatonin resulted less effective when administered early in the morning.”
Names both Clonidine and Melatonin in its title.
“The preoperative anxiolysis with melatonin or clonidine reduced postoperative pain and morphine consumption in patients undergoing abdominal hysterectomy. The effects these 2 drugs were equivalent and greater than with placebo.”
Names both Clonidine and Melatonin in its title.
“Further indication is provided for presynaptic alpha2-adrenoceptor dysfunction in depression with the application of an alternative pharmacological challenge method.”
Names both Clonidine and Melatonin in its title.
“Only clonidine 300 micrograms produced a significant elevation in GH release. This study highlights the limitations of oral neuroendocrine challenge studies.”
Names both Clonidine and Melatonin in its title.
“Melatonin, clonidine, and dexmedetomidine are efficacious for producing preoperative sedation, reducing anxiety, postoperative pain, and emergence delirium.”
Names both Clonidine and Melatonin in its title.
“Although both the drugs are effective, oral melatonin proved superior to oral clonidine in attenuating the haemodynamic response to laryngoscopy and tracheal intubation without any side effects.”
Names both Clonidine and Melatonin in its title.
Search-based evidence indexes have real limits, and it is worth being explicit about them:
NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Clonidine, Melatonin, and several hundred other substances.
Log your routine, get reminders at the times you choose, and scan a label to add a product. The checker is a research and organisation tool, not a clinical decision aid.
NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
