NutriStack
Atenolol and Melatonin, a synergy.
Beta-blockers suppress nocturnal melatonin production. Atenolol, being beta-1 selective, has a moderate effect on melatonin suppression. Supplementation may help with insomnia.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
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What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Moderate
- Source citations
- 4 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Moderate evidence
Synergy
What is happening. Beta-blockers suppress nocturnal melatonin production. Atenolol, being beta-1 selective, has a moderate effect on melatonin suppression. Supplementation may help with insomnia.
Mechanism. Beta-1 selective blockers like atenolol still partially suppress pineal melatonin synthesis, though less than non-selective agents.
Recommendation. If experiencing insomnia on atenolol, melatonin 0.5-3mg at bedtime may help.
Sources (4)
- Stoschitzky K et al. Influence of beta-blockers on melatonin release. Eur J Clin Pharmacol. 1999;55(2):111-115. PMID 10335905
- Fatemeh G, Sajjad M, Niloufar R et al.. Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.. Journal of Neurology. 2022. PMID 33417003
- Tang BHY, Manalo J, Chowdhury SR et al.. Melatonin Use in the ICU: A Systematic Review and Meta-Analysis.. Critical Care Medicine. 2025. PMID 40662882
- Chan V, Lo K. Efficacy of dietary supplements on improving sleep quality: a systematic review and meta-analysis.. Postgraduate Medical Journal. 2022. PMID 33441476
Stack Score
How this pair moves the number.
Effect on the composite score
If both Atenolol and Melatonin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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