What kind of interaction is it?

Caution: an interaction that may reduce efficacy or raise side-effect risk and warrants monitoring.

Is this interaction backed by published research?

Yes. NutriStack lists 2 citation rows for the Fluvoxamine + Melatonin pair, each linking to PubMed by PMID where available. Full sourcing methodology at https://nutristackapp.com/methodology/interactions.

Interaction databaseSupplement × PrescriptionReviewed May 2026

Fluvoxamine and Melatonin, a caution.

Q: Can I take Fluvoxamine and Melatonin together?

Possibly, but with caution. Fluvoxamine and Melatonin have a documented caution-tier interaction. Fluvoxamine is a potent CYP1A2 inhibitor, and melatonin is metabolized almost entirely by CYP1A2. Coadministration raises melatonin AUC about 17-fold and peak concentration about 12-fold in healthy volunteers. The result is exaggerated, prolonged sedation, hangover effects the next day, and unpredictable shifts in sleep-wake timing.

Q: How does this affect a NutriStack Stack Score?

-5 to your Stack Score per scored caution row.

Fluvoxamine is a potent CYP1A2 inhibitor, and melatonin is metabolized almost entirely by CYP1A2. Coadministration raises melatonin AUC about 17-fold and peak concentration about 12-fold in healthy volunteers. The result is exaggerated, prolonged sedation, hangover effects the next day, and unpredictable shifts in sleep-wake timing.

2 primary source citations. Strong evidence. Last verified May 30, 2026.

Open the interaction checker →Read the methodology

One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.

Sourcing standards·Evidence tiers

From the interaction database

What the row says.

Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.

At a glance

Substances: Fluvoxamine and Melatonin
Pair type: Caution
Evidence (highest tier): Strong
Source citations: 2 sources
Stack Score effect: −5 to your Stack Score (per scored caution row).
Scope: Supplement × Prescription
Last verified: May 30, 2026

Caution · Strong evidence

Caution

What is happening. Fluvoxamine is a potent CYP1A2 inhibitor, and melatonin is metabolized almost entirely by CYP1A2. Coadministration raises melatonin AUC about 17-fold and peak concentration about 12-fold in healthy volunteers. The result is exaggerated, prolonged sedation, hangover effects the next day, and unpredictable shifts in sleep-wake timing.

Mechanism. Fluvoxamine strongly inhibits hepatic CYP1A2, the enzyme responsible for the first metabolic step of melatonin (6-hydroxylation). Inhibition prevents first-pass and systemic clearance, producing a roughly 17-fold rise in melatonin AUC.

Recommendation. Avoid melatonin while on fluvoxamine. If a sleep aid is needed, talk to your prescriber about non-melatonin options. Even small melatonin doses (0.3-1 mg) can produce supratherapeutic blood levels in this combination.

Sources (2)

Stack Score

How this pair moves the number.

Effect on the composite score

If both Fluvoxamine and Melatonin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).

The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.

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