NutriStack
Apigenin and Melatonin, a synergy.
Apigenin is a natural flavonoid that binds GABA-A benzodiazepine receptors, promoting sleep through a different mechanism than melatonin.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Synergy
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Synergy · Emerging evidence
Synergy
What is happening. Apigenin is a natural flavonoid that binds GABA-A benzodiazepine receptors, promoting sleep through a different mechanism than melatonin.
Mechanism. Apigenin binds the benzodiazepine site on GABA-A receptors, promoting anxiolysis and sedation. Melatonin activates MT1/MT2 receptors for circadian timing. Different sleep-promoting mechanisms.
Recommendation. Andrew Huberman's sleep stack: 50mg apigenin + 0.5-2mg melatonin (optional) + magnesium for comprehensive sleep support.
Sources (1)
Stack Score
How this pair moves the number.
Effect on the composite score
If both Apigenin and Melatonin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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