NutriStack
Cannabis (THC-Dominant) and Melatonin, a caution.
Both promote sedation, so taken together they can cause additive drowsiness, grogginess, and next-day impairment.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Cannabis (THC-Dominant) and Melatonin
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 1 source
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Supplement
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Both promote sedation, so taken together they can cause additive drowsiness, grogginess, and next-day impairment.
Mechanism. Melatonin promotes sleep onset via MT1 and MT2 receptors while THC has independent sedative CNS effects; the two produce additive drowsiness.
Recommendation. Best avoided together; if combined, expect stronger sedation than either alone. Do not drive or operate machinery, and seek medical advice before combining if you take other sedating medications.
Sources (1)
- Babson KA et al, Cannabis, cannabinoids, and sleep: a review of the literature, Current Psychiatry Reports, 2017
Stack Score
How this pair moves the number.
Effect on the composite score
If both Cannabis (THC-Dominant) and Melatonin are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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