NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Aripiprazole and Cannabis (THC-Dominant): what the published research says

PubMed indexes 6 records that name Aripiprazole and Cannabis (THC-Dominant) together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Aripiprazole and Cannabis (THC-Dominant). It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

6 studies naming Aripiprazole and Cannabis (THC-Dominant).

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Aripiprazole for treating cannabis-induced psychotic symptoms in ultrahigh-risk individuals.

Clinical neuropharmacology · 2013 · PMID 23673914

Case ReportsHuman subjects

“Aripiprazole 10 mg/d could totally and durably suppress CIPSs in the patient, but had no effect on the smoking level. Treating CIPSs in ultrahigh risk individuals who cannot stop or refuse stopping cannabis might fit a harm-reduction strategy by preventing transition into psychosis.”

Rolland et al. · From the abstract

Names both Aripiprazole and Cannabis (THC-Dominant) in its title.

Program Evaluation to Aid Choice of Aripiprazole or Risperidone for Hospitalized Adolescents with Cannabis Use Disorder and Psychosis.

Journal of child and adolescent psychopharmacology · 2023 · PMID 37861990

Human subjects

“Conclusions: Adolescents hospitalized for co-occurring psychosis and cannabis use disorder had a significantly longer length of stay and length of stay index. These data are consistent with a more rapid reduction in acute psychotic symptoms for aripiprazole compared with risperidone in the context of co-occurring cannabis use disorder.”

Thurstone et al. · From the abstract

Names both Aripiprazole and Cannabis (THC-Dominant) in its title.

Atypical Antipsychotic Drugs in Dual Disorders: Current Evidence for Clinical Practice.

Current pharmaceutical design · 2022 · PMID 35747956

Meta-AnalysisHuman subjects

“The findings highlight the use of SGA for the treatment of psychotic symptoms in comorbidity with substance use. Future studies on people with dual diagnosis and focused on long-term evaluations are warranted and need to investigate the efficacy of newly introduced molecules, such as partial D2 agonists and longacting injectable antipsychotics.”

Martinotti et al. · Authors' conclusion

Names Aripiprazole and Cannabis (THC-Dominant) together in an interaction, co-administration, or pharmacokinetic context.

Clinical importance of the 5-Step Precision Medicine (5SPM) method in shared decision-making to choose the antipsychotic treatment for a patient with first-episode psychosis: a case report.

BMC psychiatry · 2026 · PMID 42106750

Case ReportsHuman subjects

“In this case, precision-guided shared decision-making was associated with treatment continuity in early psychosis by resolving an atypical adverse effect and improving clinical and functional outcomes.”

Gonzalo et al. · Authors' conclusion

Names Aripiprazole and Cannabis (THC-Dominant) together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Aripiprazole, Cannabis (THC-Dominant), and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.