NutriStack
Cannabis (THC-Dominant) and Oxycodone, a caution.
Controlled human studies show that THC-dominant cannabis can interact meaningfully with oxycodone. One respiratory study found oxycodone reduced ventilatory response and inhaled THC did not further worsen ventilation in healthy volunteers, but THC slightly increased sedation. Another study found smoked cannabis enhanced analgesia from low-dose oxycodone and increased some oxycodone abuse-liability ratings, which can make extra dosing and impairment more likely.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Cannabis (THC-Dominant) and Oxycodone
- Pair type
- Caution
- Evidence (highest tier)
- Moderate
- Source citations
- 3 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Moderate evidence
Caution
What is happening. Controlled human studies show that THC-dominant cannabis can interact meaningfully with oxycodone. One respiratory study found oxycodone reduced ventilatory response and inhaled THC did not further worsen ventilation in healthy volunteers, but THC slightly increased sedation. Another study found smoked cannabis enhanced analgesia from low-dose oxycodone and increased some oxycodone abuse-liability ratings, which can make extra dosing and impairment more likely.
Mechanism. Oxycodone activates mu-opioid receptors, producing analgesia, sedation, and dose-dependent respiratory depression. THC activates CB1 receptors and can cause sedation, impaired attention, and cannabinoid-opioid analgesic interactions; current human data do not show added ventilatory depression with oxycodone in healthy volunteers but do show sedation and behavioral-safety concerns.
Recommendation. Avoid combining THC-dominant cannabis with oxycodone unless the prescriber managing your opioid therapy knows. Do not drive, use alcohol, or add other sedatives after using both. Seek emergency help for slow breathing, inability to stay awake, repeated vomiting, confusion, or blue lips.
Sources (3)
- van Dam CJ, van der Schrier R, van Velzen M, van Lemmen M, Simons P, Kuijpers KWK, et al. Inhaled delta-9-tetrahydrocannabinol does not enhance oxycodone-induced respiratory depression: randomised controlled trial in healthy volunteers. Br J Anaesth. 2023;130(4):485-493. PMID 36725378
- Cooper ZD, Bedi G, Ramesh D, Balter R, Comer SD, Haney M. Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability. Neuropsychopharmacology. 2018;43(10):2046-2055. PMID 29463913
- Boom M, Niesters M, Sarton E, Aarts L, Smith TW, Dahan A. Non-analgesic effects of opioids: opioid-induced respiratory depression. Curr Pharm Des. 2012;18(37):5994-6004. PMID 22747535
Stack Score
How this pair moves the number.
Effect on the composite score
If both Cannabis (THC-Dominant) and Oxycodone are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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