NutriStack
Alprazolam and Oxycodone, contraindicated.
FDA Black Box Warning: Concurrent use of opioids and benzodiazepines can result in profound sedation, respiratory depression, coma, and death. This is one of the most dangerous drug-drug interactions in clinical practice.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alprazolam and Oxycodone
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. FDA Black Box Warning: Concurrent use of opioids and benzodiazepines can result in profound sedation, respiratory depression, coma, and death. This is one of the most dangerous drug-drug interactions in clinical practice.
Mechanism. Opioids depress brainstem respiratory centers via mu-receptor activation. Benzodiazepines enhance GABA-A-mediated inhibition, also depressing respiration. Combined CNS depression is synergistic, not merely additive.
Recommendation. Avoid concurrent prescribing whenever possible. If combined, use the lowest doses for the shortest duration. Inform patients about the risk of respiratory depression. Ensure naloxone is available.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alprazolam and Oxycodone are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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