NutriStack
Alprazolam and Hydrocodone, contraindicated.
FDA Black Box Warning: The combination of hydrocodone and alprazolam carries severe risk of fatal respiratory depression. This is among the most commonly co-prescribed dangerous drug combinations in the United States.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Alprazolam and Hydrocodone
- Pair type
- Contraindicated
- Evidence (highest tier)
- Strong
- Source citations
- 1 source
- Stack Score effect
- −25 to your Stack Score (per scored contraindication row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Contraindicated · Strong evidence
Contraindicated
What is happening. FDA Black Box Warning: The combination of hydrocodone and alprazolam carries severe risk of fatal respiratory depression. This is among the most commonly co-prescribed dangerous drug combinations in the United States.
Mechanism. Synergistic CNS and respiratory depression through combined mu-opioid receptor agonism and GABA-A receptor potentiation.
Recommendation. Avoid concurrent prescribing. If no alternative exists, use lowest effective doses for the shortest duration. Monitor closely for respiratory depression.
Stack Score
How this pair moves the number.
Effect on the composite score
If both Alprazolam and Hydrocodone are in the same stack, this pair applies −25 to your Stack Score (per scored contraindication row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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