Supplement × Supplement·a conflict·Strong evidence
Caffeine can delay sleep onset and counteract melatonin timing goals.
Every entry follows the same shape: what is happening, the mechanism, and the recommendation.
What is happening. Caffeine can delay sleep onset and counteract melatonin timing goals.
Mechanism. Adenosine antagonism and circadian alerting oppose melatonin-mediated sleep signaling.
Recommendation. Avoid caffeine within 8-10 hours of planned sleep if insomnia-prone.
Effect on the composite score
If both Caffeine and Melatonin are in the same stack, this pair applies −10 to your Stack Score (per scored conflict row).
The full algorithm, the clamping rules, and four worked stacks are at /methodology/stack-score.
Every claim on this page is cited. PMIDs link straight to PubMed.
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NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.
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