NutriStack
Carvedilol and Melatonin, a synergy.
Carvedilol, as a non-selective beta-blocker, suppresses nocturnal melatonin synthesis more than beta-1 selective agents. Melatonin supplementation can restore sleep quality.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
Same shape as the other 1,729 pairs in the public database.
From the interaction database
What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Substances
- Carvedilol and Melatonin
- Pair type
- Synergy
- Evidence (highest tier)
- Strong
- Source citations
- 4 sources
- Stack Score effect
- +2 to your Stack Score (per scored synergy row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Synergy · Strong evidence
Synergy
What is happening. Carvedilol, as a non-selective beta-blocker, suppresses nocturnal melatonin synthesis more than beta-1 selective agents. Melatonin supplementation can restore sleep quality.
Mechanism. Non-selective beta-blockers block pineal beta-1 and beta-2 receptors, strongly suppressing melatonin synthesis via AANAT inhibition.
Recommendation. Melatonin 0.5-3mg at bedtime may help with carvedilol-induced insomnia.
Sources (4)
- Stoschitzky K et al. Influence of beta-blockers on melatonin release. Eur J Clin Pharmacol. 1999;55(2):111-115. PMID 10335905
- Fatemeh G, Sajjad M, Niloufar R et al.. Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials.. Journal of Neurology. 2022. PMID 33417003
- Tang BHY, Manalo J, Chowdhury SR et al.. Melatonin Use in the ICU: A Systematic Review and Meta-Analysis.. Critical Care Medicine. 2025. PMID 40662882
- Chan V, Lo K. Efficacy of dietary supplements on improving sleep quality: a systematic review and meta-analysis.. Postgraduate Medical Journal. 2022. PMID 33441476
Stack Score
How this pair moves the number.
Effect on the composite score
If both Carvedilol and Melatonin are in the same stack, this pair applies +2 to your Stack Score (per scored synergy row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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