NutriStack
Apigenin and Diazepam, a caution.
Apigenin has benzodiazepine-receptor and GABA(A)-modulating activity in preclinical studies. One receptor study specifically found that apigenin enhanced diazepam's positive modulation of GABA(A) receptor activation. In people, this could mean more sedation, impaired coordination, or slowed reaction time, although direct clinical interaction trials are lacking.
One pair, every claim cited. The two substances, the type, the mechanism, the recommendation, and the primary literature.
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What the row says.
Every entry follows the same shape: what is happening, the mechanism, the recommendation, and the primary literature.
At a glance
- Pair type
- Caution
- Evidence (highest tier)
- Emerging
- Source citations
- 2 sources
- Stack Score effect
- −5 to your Stack Score (per scored caution row).
- Scope
- Supplement × Prescription
- Last verified
- May 30, 2026
Caution · Emerging evidence
Caution
What is happening. Apigenin has benzodiazepine-receptor and GABA(A)-modulating activity in preclinical studies. One receptor study specifically found that apigenin enhanced diazepam's positive modulation of GABA(A) receptor activation. In people, this could mean more sedation, impaired coordination, or slowed reaction time, although direct clinical interaction trials are lacking.
Mechanism. Apigenin can bind central benzodiazepine receptors and modulate GABA(A) receptor responses. Diazepam is a benzodiazepine positive allosteric modulator at GABA(A) receptors, so apigenin may increase net receptor-mediated CNS depressant signaling.
Recommendation. Use apigenin cautiously if you take diazepam, especially when starting either product or increasing doses. Avoid alcohol and other sedatives, and do not drive until you know how the combination affects you. Stop apigenin and contact your prescriber if sedation, confusion, or balance problems increase.
Sources (2)
- Campbell EL, Chebib M, Johnston GAR. The dietary flavonoids apigenin and (-)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABA(A) receptors. Biochem Pharmacol. 2004;68(8):1631-1638. PMID 15451406
- Viola H, Wasowski C, Levi de Stein M, Wolfman C, Silveira R, Dajas F, et al. Apigenin, a component of Matricaria recutita flowers, is a central benzodiazepine receptors-ligand with anxiolytic effects. Planta Med. 1995;61(3):213-216. PMID 7617761
Stack Score
How this pair moves the number.
Effect on the composite score
If both Apigenin and Diazepam are in the same stack, this pair applies −5 to your Stack Score (per scored caution row).
The full algorithm, the clamping rules, and four worked stacks are documented at /methodology/stack-score.
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