NSTK · 01.2026Independent supplement reference
NutriStack
Edition 1.0Updated August 1, 2026

Supplement × Prescription·Evidence index

Diazepam and Kava: what the published research says

PubMed indexes 3 records that name Diazepam and Kava together, either in the title or in an interaction, co-administration, or pharmacokinetic context. Each one is listed below with its study design and, where the abstract states one, the authors’ own conclusion, quoted and linked. This page reports that literature. It does not tell you whether to combine them.

Read this first

An evidence index, not guidance.

Every statement below is attributed to a named, dated, linked source.

This page lists published research relevant to Diazepam and Kava. It deliberately does not state whether the combination is safe, whether it interacts, in which direction, at what dose, or how far apart to take them.

The research

3 studies naming Diazepam and Kava.

Strongest relevance first: papers naming both substances in the title, then human trials and systematic reviews.

Enhanced efficacy and reduced side effects of diazepam by kava combination.

Journal of advanced research · 2014 · PMID 25685527

“control group following chronic administration of kava or DZ either alone or in combination with kava. In conclusion, the present study suggests the possibility of combining a low dose DZ with kava to reduce harmful effects and might be recommended for clinical use in patients chronically treated with this synthetic anticonvulsant drug.”

Tawfiq et al. · From the abstract

Names both Diazepam and Kava in its title.

Anxiolytic-like effects of kava-kava in the elevated plus maze test--a comparison with diazepam.

Progress in neuro-psychopharmacology & biological psychiatry · 2002 · PMID 12369257

Animal study

“LI 150 (120-240 mg/kg p.o.) affected the behaviour measured in the X-maze test, inducing an anxiolytic like behaviour similar to diazepam (15 mg/kg p.o.). These data support the use of Kava-Kava in the treatment of anxiety.”

Rex et al. · From the abstract

Names both Diazepam and Kava in its title.

Severe kava withdrawal managed with phenobarbital.

The American journal of emergency medicine · 2025 · PMID 40541460

Case ReportsHuman subjects

“While kava's pharmacologic properties remain poorly understood, withdrawal may be severe enough to warrant hospitalization. Phenobarbital or benzodiazepines may be considered as a potential therapeutic approach.”

Bleifuss et al. · From the abstract

Names Diazepam and Kava together in an interaction, co-administration, or pharmacokinetic context.

Limitations

What this evidence cannot tell you.

Search-based evidence indexes have real limits, and it is worth being explicit about them:

NutriStack

Track what you actually take.

NutriStack is a free iPhone app for organising a supplement routine: what you take, when, and what the published record says about it. Its exploratory interaction checker covers Diazepam, Kava, and several hundred other substances.

The checker is a research and organisation tool, not a clinical decision aid, and its per-pair assessments are excluded from search until they pass claim-level review.

NutriStack is an informational and organizational tool, not a medical service, and not a substitute for professional advice. Always consult a qualified healthcare professional before starting, stopping, or changing any supplement or medication.